Środowiskowe Laboratorium Microbiota Lab

Wydział Farmaceutyczny

Środowiskowe Laboratorium Microbiota Lab

Wydział Farmaceutyczny

Publikacje

  1. Tymoszewska A, Steczkiewicz K, Aleksandrzak-Piekarczyk T. An atypical V-shaped garvicin C bacteriocin targets Man-PTS via domain insertion. Biophysical Journal. 2026;125(1):99-112.
  2. Kruk A, Grześkowiak Ł, Popowski D, Tymoszewska A, Zentek J, Granica S, Piwowarski J. Potential of tormentil rhizome ethanolic extract and its postbiotic metabolites for inhibiting enterotoxigenic E. coli growth: Implications for functional food applications. Food Chemistry. 2026;500:1-59.
  3. Kostenko Y, Vlasova I, Równicki M, Krüsselmann P, Vahjen W, Zentek J, Tymoszewska A, Piwowarski J. The eubiotic perspective on utilization of tannins in phytotherapy and nutrition of pigs. Frontiers in Pharmacology. 2025;16:1-27.
  4. Korczak M, Redl M, Roszkowski P, Granica S, Rollinger J, Heiss E, Piwowarski J. Synthesis, characterization, and anti-inflammatory potential of serotonin- and dopamine-conjugates of urolithin A. Biomedicine & Pharmacotherapy. 2025;189:1-14.
  5. Vlasova I, Krüsselmann P, Kostenko Y, Obrębski M, Granica S, (...), Równicki M, Piwowarski J. The assessment of chemical composition and biological activity of faba bean pods as a potential feed additive utilized in piglets nutrition. Scientific Reports. 2025;15:1-14.
  6. Parzonko A, Filipek A, Równicki M, Kiss A. Syringin (Sinapyl Alcohol 4-O-Glucoside) Improves the Wound Healing Capacity of Fibroblasts and Keratinocytes In Vitro. International Journal of Molecular Sciences. 2025;26(16):1-15.
  7. Shahryari S, Ahmad S, Foik I, Jankowski P, Samborski A, Równicki M, Vasantham S, Garstecki P. Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach. Royal Society Open Science. 2025;12(7):1-19.
  8. Kruk A, Popowski D, Średnicka P, Roszko M, Granica S, Piwowarski J. Selective metabolism of tormentil rhizome constituents by human gut microbiota and its impact on biodiversity ex vivo. Food Chemistry. 2025;478:1-10.
  9. Kruk A. In Vitro Evaluation of Antioxidant and Cytokine-Modulating Activity of Tormentil Rhizome Extract and Its Microbial Metabolites in Human Immune Cells. International Journal of Molecular Sciences. 2025;26(22):1-23.
  10. Liudvytska O, Kowalczyk M, Krzyżanowska-Kowalczyk J, (...), Skowrońska W, Równicki M, Bazylko A, (...), Kolodziejczyk-Czepas J. Phytochemical Profiling, Anti-Inflammatory Action, and Human Gut Microbiota-Assisted Digestion of Rheum officinale Petiole and Root Extracts—An In Vitro Study. Nutrients. 2025;17(21):1-27.
  11. Kiełkiewicz R, Obrębski M, Śliwińska A, Skowrońska W, Bedra M, Osica M, Sykłowska-Baranek K. Exploring the biosynthetic efficiency of Aralia racemosa L. (Araliaceae): assessment of triterpenoid saponins and phenolic compounds production in plantlets, callus, and cell suspension cultures. Industrial Crops and Products. 2025;234:1-32.
  12. Singla R, Mondal H, Singla S, (...), Granica S, (...), Stolarczyk A, (...), Ławiński M, (...), Shen B. Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey. Current Research in Biotechnology. 2025;9:1-14.
  13. Skowrońska W, Pawłowska K, Obrębski M, Piwowarski J, Żyżyńska-Granica B, Granica S. Chemical composition, skin microbiota metabolism, antimicrobial potential and anti-inflammatory properties of witch hazel bark (Hamamelis virginiana L.). Journal of Ethnopharmacology. 2025;353(Part B):1-18.
  14. El Boukhari R, Matin M, Bouissane L, Ławiński M, (...), Łapiński M, Stolarczyk A, (...), Piwowarski J, (...), Atanasov A. Enhancing human gut health: Global innovations in dysbiosis management. iMeta. 2025;4(3):1-12.
  15. Berecka-Rycerz A, Chrząszcz-Wróbel M, Matwijczuk A, Hołowiński P, Granica S, Dos Santos Szewczyk K. Membrane-Active Phenolic Compounds from Cephalaria uralensis (Murray) Roem. & Schult.: Isolation, Structural Characterization, and Antioxidant Potential. Applied Sciences. 2025;15(17):1-16.
  16. Obrębski M, Kiełkiewicz R, Tomiczak K, Śliwińska A. Defining Phytochemical Metabolomes of Somatic Hybrids Gentiana cruciata L. (+) G. tibetica King ex Hook.f. (Gentianaceae) Using UHPLC-DAD-ESI-MS3 Analysis in Comparison to the Parental Species. Molecules. 2025;30(16):1-39.
  17. Jakimiuk K, Kruk A, Lemieszek M, Strawa J, Granica S, Wiater A, Tomczyk M. Ex vivo biotransformation of lady’s mantle extracts via the human gut microbiota: the formation of phenolic metabolites and their impact on human normal and colon cancer cell lines. Frontiers in Pharmacology. 2025;16:1-11.
  18. Verhelst R, Kruk A. Integrated Molecular and Functional Analysis of Hop Ethanolic Extract in Caco-2 Cells: Insights into Inflammation, Barrier Function, and Transport. International Journal of Molecular Sciences. 2025;26(21):1-24.
  19. Melnyk N, Nyczka A, Piwowarski J, Granica S. Traditional Use of Chamomile Flowers (Matricariae flos) in Inflammatory-Associated Skin Disorders. Prospects in Pharmaceutical Sciences. 2024;22(4):59-73.
  20. Tymoszewska A, Aleksandrzak-Piekarczyk T. Badania nad mechanizmami działania i rozwoju oporności na bakteriocyny klasy II u bakterii Gram-dodatnich. Postępy Biochemii. 2024;70(2):266-278.
  21. Kiełkiewicz R, Obrębski M, Śliwińska A, Równicki M, Kawka M, Sykłowska-Baranek K, Granica S. Detailed qualitative and quantitative UHPLC-DAD-ESI-MS3 analysis of Aralia spinosa L. (Araliaceae) phytochemical profile to evaluate its potential as novel plant material for bioactive compounds acquisition using in vitro culture. Industrial Crops and Products. 2024;219:1-31.
  22. Jafernik K, Kokotkiewicz A, Dziurka M, Kruk A, (...), Granica S, (...), Szopa A. Phytochemical Profiling and Biological Activities of Extracts from Bioreactor-Grown Suspension Cell Cultures of Schisandra henryi. Molecules. 2024;29(22):1-18.
  23. Jafernik K, Kubica P, Sharafan M, Kruk A, Malinowska M, Granica S, Szopa A. Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures. Applied Microbiology and Biotechnology. 2024;108(1):1-13.
  24. Snarska J, Jakimiuk K, Strawa J, Tomczyk T, Tomczykowa M, Piwowarski J, Tomczyk M. A Comprehensive Review of Pedunculagin: Sources, Chemistry, Biological and Pharmacological Insights. International Journal of Molecular Sciences. 2024;25(21):1-18.
  25. Kruk A, Popowski D, Roszko M, Granica S, Piwowarski J. Heterogeneity of transport and metabolism of Tormentillae rhizoma constituents across human intestinal epithelium cellular model. Food Research International. 2024;188:1-11.
  26. Dolzhko D, Melnyk N, Kruk A, Granica S, Piwowarski J. Traditional use of polar extracts from lavender flowers – systematic review of literature data. Prospects in Pharmaceutical Sciences. 2024;22(3):92-101.
  27. Kołodziej P, Wujec M, Doligalska M, (...), Granica S, (...), Bogucka-Kocka A. Synthesis and anthelmintic activity of novel thiosemicarbazide and 1,2,4-triazole derivatives: In vitro, in vivo, and in silico study. Journal of Advanced Research. 2024;60:57-73.
  28. Melnyk N, Popowski D, Strawa J, Przygodzińska K, Tomczyk M, Piwowarski J, Granica S. Skin microbiota metabolism of natural products from comfrey root (Symphytum officinale L.). Journal of Ethnopharmacology. 2024;318(Pt B):1-10.
  29. Popowski D, Kruk A, Pawłowska K, Dolzhko D, Korczak M, Piwowarski J, Roszko M, Granica S. Evaluating birch leaf tea as a functional herbal beverage: Beneficial impact on the urinary tract, and metabolism in human organism. Food Research International. 2024;189:1-11.
  30. Hochrainer N, Serafin P, D'Ingiullo S, Mollica A, Granica S, Brytan M, Kleczkowska P, Spetea M. In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin–Ranatensin Hybrid Peptide. International Journal of Molecular Sciences. 2024;25(7):1-17.
  31. Skowrońska W, Granica S, Piwowarski J, Jakupović L, Zovko-Koncić M, Bazylko A. Wound healing potential of extract from Sambucus nigra L. leaves and its fractions. Journal of Ethnopharmacology. 2024;320:1-16.
  32. Tymoszewska A, Aleksandrzak-Piekarczyk T. Subclass IId bacteriocins targeting mannose phosphotransferase system—Structural diversity and implications for receptor interaction and antimicrobial activity. PNAS Nexus. 2024;3(9):1-13.
  33. Korczak M, Roszkowski P, Skowrońska W, Żołdak K, Popowski D, Granica S, Piwowarski J. Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function. Biomedicine & Pharmacotherapy. 2023;169:1-12.
  34. Korczak M, Pilecki M, Granica S, Gorczynska A, Pawłowska K, Piwowarski J. Phytotherapy of mood disorders in the light of microbiota-gut-brain axis. Phytomedicine. 2023;111:1-21.
  35. Saber F, Elosaily A, Mahrous E, (...), Korczak M, Piwowarski J, (...), Skalicka-Woźniak K. Detailed metabolite profiling and in vitro studies of Urospermum picroides as a potential functional food. Food Chemistry. 2023;427:1-12.
  36. Koshovyi O, Vlasova I, Laur H, (...), Granica S, Piwowarski J, (...), Raal A. Chemical Composition and Insulin-Resistance Activity of Arginine-Loaded American Cranberry (Vaccinium macrocarpon Aiton, Ericaceae) Leaf Extracts. Pharmaceutics. 2023;15(11):1-18.
  37. Sobolewska D, Galanty A, Granica S, Podolak I, Olszewska M, Owczarek A, Palino N, Michalska K. In vitro cytotoxic activity of Cuphea ingrata Cham. & Schltdl. extracts related to the oenothein B content. Natural Product Research. 2023;37(10):1693-1697.
  38. Singla R, De R, Efferth T, (...), Granica S, (...), Shen B. The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. Phytomedicine. 2023;108:1-15.
  39. Dos Santos Szewczyk K, Skowrońska W, Kruk A, Makuch-Kocka A, Bogucka-Kocka A, Miazga-Karska M, Grzywa-Celińska A, Granica S. Chemical composition of extracts from leaves, stems and roots of wasabi (Eutrema japonicum) and their anti-cancer, anti-inflammatory and anti-microbial activities. Scientific Reports. 2023;13:1-12.
  40. Bandick R, Busmann L, Mousavi S, (...), Piwowarski J, Granica S, (...), Heimesaat M. Therapeutic Effects of Oral Application of Menthol and Extracts from Tormentil (Potentilla erecta), Raspberry Leaves (Rubus idaeus), and Loosestrife (Lythrum salicaria) during Acute Murine Campylobacteriosis. Pharmaceutics. 2023;15(10):1-23.
  41. Pawłowska K, Kryżman M, Zidorn C, Pagitz K, Popowski D, Granica S. HPLC-DAD-MS3 fingerprints of phenolics of selected Polygonum taxa and their chemometric analysis. Phytochemistry. 2023;208:1-14.
  42. Średnicka P, Roszko M, Popowski D, (...), Juszczuk-Kubiak E. Effect of in vitro cultivation on human gut microbiota composition using 16S rDNA amplicon sequencing and metabolomics approach. Scientific Reports. 2023;13(1):1-25.
  43. Kowalczyk M, Piwowarski J, Wardaszka A, Średnicka P, Wójcicki M, Juszczuk-Kubiak E. Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants—A Review. International Journal of Molecular Sciences. 2023;24(2):1-64.
  44. Pawłowska K, Baracz T, Skowrońska W, Piwowarski J, Majdan M, (...), Granica S. The contribution of phenolics to the anti-inflammatory potential of the extract from Bolivian coriander (Porophyllum ruderale subsp. ruderale). Food Chemistry. 2022;371:1-11.
  45. Piwowarski J, Stanisławska I, Granica S. Dietary polyphenol and microbiota interactions in the context of prostate health. Annals of the New York Academy of Sciences. 2022;1508(1):54-77.
  46. Skowrońska W, Granica S, Czerwińska M, Osińska E, Bazylko A. Sambucus nigra L. leaves inhibit TNF-α secretion by LPS-stimulated human neutrophils and strongly scavenge reactive oxygen species. Journal of Ethnopharmacology. 2022;290:1-11.
  47. Melnyk N, Vlasova I, Skowrońska W, Bazylko A, Piwowarski J, Granica S. Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota. International Journal of Molecular Sciences. 2022;23(17):1-28.
  48. Magiera A, Czerwińska M, Owczarek A, Marchelak A, Granica S, Olszewska M. Polyphenol-enriched extracts of Prunus spinosa fruits: anti-Inflammatory and antioxidant effects in human immune cells ex vivo in relation to phytochemical profile. Molecules. 2022;27(5):1-19.
  49. Kruk A, Gadomska-Gajadhur A, Dulnik J, Ruśkowski P. The influence of the molecular weight of polymer on the morphology, functional properties and L929 fibroblasts growth on polylactide membranes for tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. 2022;71(1):45-57.
  50. Korczak M, Roszkowski P, Granica S, Piwowarski J. Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential. Scientific Reports. 2022;12:1-15.
  51. Michel P, Granica S, Rosińska K, Glige M, Rojek J, Poraj Ł, Olszewska M. The Effect of Standardised Leaf Extracts of Gaultheria procumbens on Multiple Oxidants, Inflammation-Related Enzymes, and Pro-Oxidant and Pro-Inflammatory Functions of Human Neutrophils. Molecules. 2022;27(10):1-17.
  52. Wasyłeczko M, Krysiak Z, Łukowska E, (...), Kruk A, (...), Chwojnowski A. Three-dimensional scaffolds for bioengineering of cartilage tissue. Biocybernetics and Biomedical Engineering. 2022;42(2):494-511.
  53. Luca S, Kulinowski Ł, Ciobanu C, (...), Czerwińska M, Granica S, (...), Trifan A. Phytochemical and multi-biological characterization of two Cynara scolymus L. varieties: A glance into their potential large scale cultivation and valorization as bio-functional ingredients. Industrial Crops and Products. 2022;178:1-9.
  54. Żyżyńska-Granica B, Mollica A, Stefanucci A, Granica S, Kleczkowska P. Comparative Study of Chemical Stability of a PK20 Opioid–Neurotensin Hybrid Peptide and Its Analogue [Ile9]PK20—The Effect of Isomerism of a Single Amino Acid. International Journal of Molecular Sciences. 2022;23(18):1-14.
  55. Popowski D, Zentek J, Piwowarski J, Granica S. Gut Microbiota of Pigs Metabolizes Extracts of Filipendula ulmaria and Orthosiphon aristatus-Herbal Remedies Used in Urinary Tract Disorders. Planta Medica. 2022;88(03/04):254-261.
  56. Kruk A, Granica S, Popowski D, Malinowska N, Piwowarski J. Tiliae flos metabolites and their beneficial influence on human gut microbiota biodiversity ex vivo. Journal of Ethnopharmacology. 2022;294:1-12.
  57. Magiera A, Czerwińska M, Owczarek A, Marchelak A, Granica S, Olszewska M. Polyphenols and Maillard Reaction Products in Dried Prunus spinosa Fruits: Quality Aspects and Contribution to Anti-Inflammatory and Antioxidant Activity in Human Immune Cells Ex Vivo. Molecules. 2022;27(10):1-21.
  58. Jakimiuk K, Strawa J, Granica S, Locatelli M, Tartaglia A, Tomczyk M. Determination of Flavonoids in Selected Scleranthus Species and Their Anti-Collagenase and Antioxidant Potential. Molecules. 2022;27(6):1-16.
  59. Lacret R, Puerta A, Granica S, (...), Padron J. Bioactive Potential: A Pharmacognostic Definition through the Screening of Four Hypericum Species from the Canary Islands. Molecules. 2022;27(18):1-18.
  60. Gadomska-Gajadhur A, Kruk A, Ruśkowski P, Sajkiewicz P, Dulnik J, Chwojnowski A. Original method of imprinting pores in scaffolds for tissue engineering. Polymers for Advanced Technologies. 2021;32(1):355-367.
  61. Siegień J, Buchholz T, Popowski D, Granica S, Osińska E, Melzig M, Czerwińska M. Pancreatic lipase and α-amylase inhibitory activity of extracts from selected plant materials after gastrointestinal digestion in vitro. Food Chemistry. 2021;355:1-13.
  62. Popowski D, Pawłowska K, Deipenbrock M, Hensel A, Kruk A, Melzig M, Piwowarski J, Granica S. Antiadhesive activity of hydroethanolic extract from bean pods of Phaseolus vulgaris (common bean) against uropathogenic E. coli and permeability of its constituents through Caco-2 cells monolayer. Journal of Ethnopharmacology. 2021;274:1-11.
  63. Gumieniczek A, Berecka-Rycerz A, Fornal E, Żyżyńska-Granica B, Granica S. Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA). Molecules. 2021;26(18):1-28.
  64. Gadomska-Gajadhur A, Kruk A, Wierzchowski K, Ruskowski P, Pilarek M. Design of experiments-based strategy for development and optimization of polylactide membranes preparation by wet inversion phase method. Polymers for Advanced Technologies. 2021;32(8):3028-3038.
  65. Skowrońska W, Granica S, Dziedzic M, Kurkowiak J, Ziaja M, Bazylko A. Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots. Plants. 2021;10(1):1-19.
  66. Trifan A, Luca S, Bostănaru A, (...), Granica S, Czerwińska M, Kruk A, (...), Mareș M. Apiaceae essential oils: boosters of terbinafine activity against dermatophytes and potent anti-inflammatory effectors. Plants. 2021;10(11):1-17.
  67. Gadomska-Gajadhur A, Kruk A, Judyta D, Chwojnowski A. New polyester biodegradable scaffolds for chondrocyte culturing: Preparation, properties, and biological activity. Journal of Applied Polymer Science. 2021;138(13):1-14.
  68. Olszewska M, Owczarek A, Magiera A, Granica S, Michel P. Screening for the Active Anti-Inflammatory and Antioxidant Polyphenols of Gaultheria procumbens and Their Application for Standardisation: From Identification through Cellular Studies to Quantitative Determination. International Journal of Molecular Sciences. 2021;22(21):1-21.
  69. Młotek M, Gadmoska-Gajadhur A, Sobczak A, Kruk A, Perron M, Krawczyk K. Modification of PLA Scaffold Surface for Medical Applications. Applied Sciences. 2021;11(4):1-12.
  70. Melnyk N, Pawłowska K, Ziaja M, Wojnowski W, Koshovyi O, Granica S, Bazylko A. Characterization of herbal teas containing lime flowers - Tiliae flos by HPTLC method with chemometric analysis. Food Chemistry. 2021;346:1-9.
  71. Koshovyi O, Granica S, Piwowarski J, Stremoukhov O, Kostenko Y, Kravchenko G, Krasilnikowa O, Zagayko A. Highbush Blueberry (Vaccinium corymbosum L.) Leaves Extract and Its Modified Arginine Preparation for the Management of Metabolic Syndrome—Chemical Analysis and Bioactivity in Rat Model. Nutrients. 2021;13(8):1-18.
  72. Trifan A, Bostănaru A, Luca S, (...), Granica S, Czerwińska M, Kruk A, (...), Schuster D. Honokiol and magnolol: insights into their antidermatophytic effects. Plants. 2021;10(11):1-16.
  73. Piwowarski J. Jenseits der antinutritiven Eigenschaften von Gerbstoffen. Neue Untersuchungen zur Wirkung an Ferkeln. Zeitschrift für Phytotherapie. 2021;42(1):31-37.
  74. Popowski D, Czerwińska M, Kruk A, Pawłowska K, Zentek J, Melzig M, Piwowarski J, Granica S. Gut microbiota metabolism and the permeability of natural products contained in infusions from herb of European goldenrod Solidago virgaurea L. Journal of Ethnopharmacology. 2021;273:1-12.
  75. Jakimiuk K, Strawa J, Granica S, Tomczyk M. New Flavone C-Glycosides from Scleranthus perennis and Their Anti-Collagenase Activity. Molecules. 2021;26(18):1-10.
  76. Bobowska A, Granica S, Filipek A, Melzig M, Moeslinger T, Zentek J, Kruk A, Piwowarski J. Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions. European Journal of Nutrition. 2021;60(4):1957-1972.
  77. Kruk A, Piwowarski J, Pawłowska K, Popowski D, Granica S. High molecular pyrogens present in plant extracts interfere with examinations of their immunomodulatory properties in vitro. Scientific Reports. 2021;11(1):1-12.
  78. Gadomska-Gajadhur A, Ruskowski P, Kruk A, Mierzejewska J. Kinetics of neomycin release from polylactide spheres and its antimicrobial activity. Polimery w Medycynie. 2021;51(1):17-24.
  79. Tymoszewska A, Pietruczuk-Padzik A, Laskowska A. ĆWICZENIE 4: Oznaczanie lekowrażliwości drobnoustrojów. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 40-52.
  80. Laskowska A, Równicki M, Makuch I. ĆWICZENIE 1: Monitoring mikrobiologiczny środowiska wytwarzania produktów farmaceutycznych. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 95-101.
  81. Tymoszewska A. ĆWICZENIE 3: Metody liczenia drobnoustrojów. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 35-39.
  82. Równicki M. ĆWICZENIE 5: Probiotyki. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 118-126.