Środowiskowe Laboratorium Microbiota Lab

Wydział Farmaceutyczny

Środowiskowe Laboratorium Microbiota Lab

Wydział Farmaceutyczny

Publikacje

  1. Kruk A, Popowski D, Średnicka P, Roszko M, Granica S, Piwowarski J. Selective metabolism of tormentil rhizome constituents by human gut microbiota and its impact on biodiversity ex vivo. Food Chemistry. 2025;478:1-10.
  2. Verhelst R, Kruk A. Integrated Molecular and Functional Analysis of Hop Ethanolic Extract in Caco-2 Cells: Insights into Inflammation, Barrier Function, and Transport. International Journal of Molecular Sciences. 2025;26(21):1-24.
  3. Jakimiuk K, Kruk A, Lemieszek M, Strawa J, Granica S, Wiater A, Tomczyk M. Ex vivo biotransformation of lady’s mantle extracts via the human gut microbiota: the formation of phenolic metabolites and their impact on human normal and colon cancer cell lines. Frontiers in Pharmacology. 2025;16:1-11.
  4. Obrębski M, Kiełkiewicz R, Tomiczak K, Śliwińska A. Defining Phytochemical Metabolomes of Somatic Hybrids Gentiana cruciata L. (+) G. tibetica King ex Hook.f. (Gentianaceae) Using UHPLC-DAD-ESI-MS3 Analysis in Comparison to the Parental Species. Molecules. 2025;30(16):1-39.
  5. Kostenko Y, Vlasova I, Równicki M, Krüsselmann P, Vahjen W, Zentek J, Tymoszewska A, Piwowarski J. The eubiotic perspective on utilization of tannins in phytotherapy and nutrition of pigs. Frontiers in Pharmacology. 2025;16:1-27.
  6. Parzonko A, Filipek A, Równicki M, Kiss A. Syringin (Sinapyl Alcohol 4-O-Glucoside) Improves the Wound Healing Capacity of Fibroblasts and Keratinocytes In Vitro. International Journal of Molecular Sciences. 2025;26(16):1-15.
  7. Shahryari S, Ahmad S, Foik I, Jankowski P, Samborski A, Równicki M, Vasantham S, Garstecki P. Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach. Royal Society Open Science. 2025;12(7):1-19.
  8. Korczak M, Redl M, Roszkowski P, Granica S, Rollinger J, Heiss E, Piwowarski J. Synthesis, characterization, and anti-inflammatory potential of serotonin- and dopamine-conjugates of urolithin A. Biomedicine & Pharmacotherapy. 2025;189:1-14.
  9. Kiełkiewicz R, Obrębski M, Śliwińska A, Skowrońska W, Bedra M, Osica M, Sykłowska-Baranek K. Exploring the biosynthetic efficiency of Aralia racemosa L. (Araliaceae): assessment of triterpenoid saponins and phenolic compounds production in plantlets, callus, and cell suspension cultures. Industrial Crops and Products. 2025;234:1-32.
  10. Kruk A. In Vitro Evaluation of Antioxidant and Cytokine-Modulating Activity of Tormentil Rhizome Extract and Its Microbial Metabolites in Human Immune Cells. International Journal of Molecular Sciences. 2025;26(22):1-23.
  11. Vlasova I, Krüsselmann P, Kostenko Y, Obrębski M, Granica S, (...), Równicki M, Piwowarski J. The assessment of chemical composition and biological activity of faba bean pods as a potential feed additive utilized in piglets nutrition. Scientific Reports. 2025;15:1-14.
  12. Skowrońska W, Pawłowska K, Obrębski M, Piwowarski J, Żyżyńska-Granica B, Granica S. Chemical composition, skin microbiota metabolism, antimicrobial potential and anti-inflammatory properties of witch hazel bark (Hamamelis virginiana L.). Journal of Ethnopharmacology. 2025;353(Part B):1-18.
  13. Singla R, Mondal H, Singla S, (...), Granica S, (...), Stolarczyk A, (...), Ławiński M, (...), Shen B. Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey. Current Research in Biotechnology. 2025;9:1-14.
  14. El Boukhari R, Matin M, Bouissane L, Ławiński M, (...), Łapiński M, Stolarczyk A, (...), Piwowarski J, (...), Atanasov A. Enhancing human gut health: Global innovations in dysbiosis management. iMeta. 2025;4(3):1-12.
  15. Berecka-Rycerz A, Chrząszcz-Wróbel M, Matwijczuk A, Hołowiński P, Granica S, Dos Santos Szewczyk K. Membrane-Active Phenolic Compounds from Cephalaria uralensis (Murray) Roem. & Schult.: Isolation, Structural Characterization, and Antioxidant Potential. Applied Sciences. 2025;15(17):1-16.
  16. Snarska J, Jakimiuk K, Strawa J, Tomczyk T, Tomczykowa M, Piwowarski J, Tomczyk M. A Comprehensive Review of Pedunculagin: Sources, Chemistry, Biological and Pharmacological Insights. International Journal of Molecular Sciences. 2024;25(21):1-18.
  17. Kiełkiewicz R, Obrębski M, Śliwińska A, Równicki M, Kawka M, Sykłowska-Baranek K, Granica S. Detailed qualitative and quantitative UHPLC-DAD-ESI-MS3 analysis of Aralia spinosa L. (Araliaceae) phytochemical profile to evaluate its potential as novel plant material for bioactive compounds acquisition using in vitro culture. Industrial Crops and Products. 2024;219:1-31.
  18. Jafernik K, Kokotkiewicz A, Dziurka M, Kruk A, (...), Granica S, (...), Szopa A. Phytochemical Profiling and Biological Activities of Extracts from Bioreactor-Grown Suspension Cell Cultures of Schisandra henryi. Molecules. 2024;29(22):1-18.
  19. Jafernik K, Kubica P, Sharafan M, Kruk A, Malinowska M, Granica S, Szopa A. Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures. Applied Microbiology and Biotechnology. 2024;108(1):1-13.
  20. Skowrońska W, Granica S, Piwowarski J, Jakupović L, Zovko-Koncić M, Bazylko A. Wound healing potential of extract from Sambucus nigra L. leaves and its fractions. Journal of Ethnopharmacology. 2024;320:1-16.
  21. Hochrainer N, Serafin P, D'Ingiullo S, Mollica A, Granica S, Brytan M, Kleczkowska P, Spetea M. In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin–Ranatensin Hybrid Peptide. International Journal of Molecular Sciences. 2024;25(7):1-17.
  22. Melnyk N, Popowski D, Strawa J, Przygodzińska K, Tomczyk M, Piwowarski J, Granica S. Skin microbiota metabolism of natural products from comfrey root (Symphytum officinale L.). Journal of Ethnopharmacology. 2024;318(Pt B):1-10.
  23. Kołodziej P, Wujec M, Doligalska M, (...), Granica S, (...), Bogucka-Kocka A. Synthesis and anthelmintic activity of novel thiosemicarbazide and 1,2,4-triazole derivatives: In vitro, in vivo, and in silico study. Journal of Advanced Research. 2024;60:57-73.
  24. Popowski D, Kruk A, Pawłowska K, Dolzhko D, Korczak M, Piwowarski J, Roszko M, Granica S. Evaluating birch leaf tea as a functional herbal beverage: Beneficial impact on the urinary tract, and metabolism in human organism. Food Research International. 2024;189:1-11.
  25. Kruk A, Popowski D, Roszko M, Granica S, Piwowarski J. Heterogeneity of transport and metabolism of Tormentillae rhizoma constituents across human intestinal epithelium cellular model. Food Research International. 2024;188:1-11.
  26. Dos Santos Szewczyk K, Skowrońska W, Kruk A, Makuch-Kocka A, Bogucka-Kocka A, Miazga-Karska M, Grzywa-Celińska A, Granica S. Chemical composition of extracts from leaves, stems and roots of wasabi (Eutrema japonicum) and their anti-cancer, anti-inflammatory and anti-microbial activities. Scientific Reports. 2023;13:1-12.
  27. Kowalczyk M, Piwowarski J, Wardaszka A, Średnicka P, Wójcicki M, Juszczuk-Kubiak E. Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants—A Review. International Journal of Molecular Sciences. 2023;24(2):1-64.
  28. Średnicka P, Roszko M, Popowski D, (...), Juszczuk-Kubiak E. Effect of in vitro cultivation on human gut microbiota composition using 16S rDNA amplicon sequencing and metabolomics approach. Scientific Reports. 2023;13(1):1-25.
  29. Saber F, Elosaily A, Mahrous E, (...), Korczak M, Piwowarski J, (...), Skalicka-Woźniak K. Detailed metabolite profiling and in vitro studies of Urospermum picroides as a potential functional food. Food Chemistry. 2023;427:1-12.
  30. Koshovyi O, Vlasova I, Laur H, (...), Granica S, Piwowarski J, (...), Raal A. Chemical Composition and Insulin-Resistance Activity of Arginine-Loaded American Cranberry (Vaccinium macrocarpon Aiton, Ericaceae) Leaf Extracts. Pharmaceutics. 2023;15(11):1-18.
  31. Singla R, De R, Efferth T, (...), Granica S, (...), Shen B. The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. Phytomedicine. 2023;108:1-15.
  32. Korczak M, Pilecki M, Granica S, Gorczynska A, Pawłowska K, Piwowarski J. Phytotherapy of mood disorders in the light of microbiota-gut-brain axis. Phytomedicine. 2023;111:1-21.
  33. Korczak M, Roszkowski P, Skowrońska W, Żołdak K, Popowski D, Granica S, Piwowarski J. Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function. Biomedicine & Pharmacotherapy. 2023;169:1-12.
  34. Sobolewska D, Galanty A, Granica S, Podolak I, Olszewska M, Owczarek A, Palino N, Michalska K. In vitro cytotoxic activity of Cuphea ingrata Cham. & Schltdl. extracts related to the oenothein B content. Natural Product Research. 2023;37(10):1693-1697.
  35. Pawłowska K, Kryżman M, Zidorn C, Pagitz K, Popowski D, Granica S. HPLC-DAD-MS3 fingerprints of phenolics of selected Polygonum taxa and their chemometric analysis. Phytochemistry. 2023;208:1-14.
  36. Bandick R, Busmann L, Mousavi S, (...), Piwowarski J, Granica S, (...), Heimesaat M. Therapeutic Effects of Oral Application of Menthol and Extracts from Tormentil (Potentilla erecta), Raspberry Leaves (Rubus idaeus), and Loosestrife (Lythrum salicaria) during Acute Murine Campylobacteriosis. Pharmaceutics. 2023;15(10):1-23.
  37. Luca S, Kulinowski Ł, Ciobanu C, (...), Czerwińska M, Granica S, (...), Trifan A. Phytochemical and multi-biological characterization of two Cynara scolymus L. varieties: A glance into their potential large scale cultivation and valorization as bio-functional ingredients. Industrial Crops and Products. 2022;178:1-9.
  38. Żyżyńska-Granica B, Mollica A, Stefanucci A, Granica S, Kleczkowska P. Comparative Study of Chemical Stability of a PK20 Opioid–Neurotensin Hybrid Peptide and Its Analogue [Ile9]PK20—The Effect of Isomerism of a Single Amino Acid. International Journal of Molecular Sciences. 2022;23(18):1-14.
  39. Magiera A, Czerwińska M, Owczarek A, Marchelak A, Granica S, Olszewska M. Polyphenols and Maillard Reaction Products in Dried Prunus spinosa Fruits: Quality Aspects and Contribution to Anti-Inflammatory and Antioxidant Activity in Human Immune Cells Ex Vivo. Molecules. 2022;27(10):1-21.
  40. Lacret R, Puerta A, Granica S, (...), Padron J. Bioactive Potential: A Pharmacognostic Definition through the Screening of Four Hypericum Species from the Canary Islands. Molecules. 2022;27(18):1-18.
  41. Piwowarski J, Stanisławska I, Granica S. Dietary polyphenol and microbiota interactions in the context of prostate health. Annals of the New York Academy of Sciences. 2022;1508(1):54-77.
  42. Pawłowska K, Baracz T, Skowrońska W, Piwowarski J, Majdan M, (...), Granica S. The contribution of phenolics to the anti-inflammatory potential of the extract from Bolivian coriander (Porophyllum ruderale subsp. ruderale). Food Chemistry. 2022;371:1-11.
  43. Skowrońska W, Granica S, Czerwińska M, Osińska E, Bazylko A. Sambucus nigra L. leaves inhibit TNF-α secretion by LPS-stimulated human neutrophils and strongly scavenge reactive oxygen species. Journal of Ethnopharmacology. 2022;290:1-11.
  44. Magiera A, Czerwińska M, Owczarek A, Marchelak A, Granica S, Olszewska M. Polyphenol-enriched extracts of Prunus spinosa fruits: anti-Inflammatory and antioxidant effects in human immune cells ex vivo in relation to phytochemical profile. Molecules. 2022;27(5):1-19.
  45. Korczak M, Roszkowski P, Granica S, Piwowarski J. Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential. Scientific Reports. 2022;12:1-15.
  46. Melnyk N, Vlasova I, Skowrońska W, Bazylko A, Piwowarski J, Granica S. Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota. International Journal of Molecular Sciences. 2022;23(17):1-28.
  47. Michel P, Granica S, Rosińska K, Glige M, Rojek J, Poraj Ł, Olszewska M. The Effect of Standardised Leaf Extracts of Gaultheria procumbens on Multiple Oxidants, Inflammation-Related Enzymes, and Pro-Oxidant and Pro-Inflammatory Functions of Human Neutrophils. Molecules. 2022;27(10):1-17.
  48. Popowski D, Zentek J, Piwowarski J, Granica S. Gut Microbiota of Pigs Metabolizes Extracts of Filipendula ulmaria and Orthosiphon aristatus-Herbal Remedies Used in Urinary Tract Disorders. Planta Medica. 2022;88(03/04):254-261.
  49. Kruk A, Granica S, Popowski D, Malinowska N, Piwowarski J. Tiliae flos metabolites and their beneficial influence on human gut microbiota biodiversity ex vivo. Journal of Ethnopharmacology. 2022;294:1-12.
  50. Jakimiuk K, Strawa J, Granica S, Locatelli M, Tartaglia A, Tomczyk M. Determination of Flavonoids in Selected Scleranthus Species and Their Anti-Collagenase and Antioxidant Potential. Molecules. 2022;27(6):1-16.
  51. Piwowarski J. Jenseits der antinutritiven Eigenschaften von Gerbstoffen. Neue Untersuchungen zur Wirkung an Ferkeln. Zeitschrift für Phytotherapie. 2021;42(1):31-37.
  52. Olszewska M, Owczarek A, Magiera A, Granica S, Michel P. Screening for the Active Anti-Inflammatory and Antioxidant Polyphenols of Gaultheria procumbens and Their Application for Standardisation: From Identification through Cellular Studies to Quantitative Determination. International Journal of Molecular Sciences. 2021;22(21):1-21.
  53. Trifan A, Bostănaru A, Luca S, (...), Granica S, Czerwińska M, Kruk A, (...), Schuster D. Honokiol and magnolol: insights into their antidermatophytic effects. Plants. 2021;10(11):1-16.
  54. Koshovyi O, Granica S, Piwowarski J, Stremoukhov O, Kostenko Y, Kravchenko G, Krasilnikowa O, Zagayko A. Highbush Blueberry (Vaccinium corymbosum L.) Leaves Extract and Its Modified Arginine Preparation for the Management of Metabolic Syndrome—Chemical Analysis and Bioactivity in Rat Model. Nutrients. 2021;13(8):1-18.
  55. Popowski D, Pawłowska K, Deipenbrock M, Hensel A, Kruk A, Melzig M, Piwowarski J, Granica S. Antiadhesive activity of hydroethanolic extract from bean pods of Phaseolus vulgaris (common bean) against uropathogenic E. coli and permeability of its constituents through Caco-2 cells monolayer. Journal of Ethnopharmacology. 2021;274:1-11.
  56. Gumieniczek A, Berecka-Rycerz A, Fornal E, Żyżyńska-Granica B, Granica S. Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA). Molecules. 2021;26(18):1-28.
  57. Trifan A, Luca S, Bostănaru A, (...), Granica S, Czerwińska M, Kruk A, (...), Mareș M. Apiaceae essential oils: boosters of terbinafine activity against dermatophytes and potent anti-inflammatory effectors. Plants. 2021;10(11):1-17.
  58. Jakimiuk K, Strawa J, Granica S, Tomczyk M. New Flavone C-Glycosides from Scleranthus perennis and Their Anti-Collagenase Activity. Molecules. 2021;26(18):1-10.
  59. Tymoszewska A. ĆWICZENIE 3: Metody liczenia drobnoustrojów. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 35-39.
  60. Laskowska A, Równicki M, Makuch I. ĆWICZENIE 1: Monitoring mikrobiologiczny środowiska wytwarzania produktów farmaceutycznych. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 95-101.
  61. Tymoszewska A, Pietruczuk-Padzik A, Laskowska A. ĆWICZENIE 4: Oznaczanie lekowrażliwości drobnoustrojów. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 40-52.
  62. Równicki M. ĆWICZENIE 5: Probiotyki. W: Mikrobiologia : skrypt do ćwiczeń dla studentów kierunku farmacja. Wyd. I. Warszawa: Warszawski Uniwersytet Medyczny, 2025. Str. 118-126.